Palabras clave
cáncer de mama
farmacología de la red
objetivo de la acción
acoplamiento molecular antidesma bunius
breast cancer
network pharmacology
target of action
molecular docking
Cómo citar
Resumen
El fruto de Antidesma bunius tiene propiedades medicinales y comestibles. En estudios anteriores, el extracto de fruta de A. bunius mostró actividad antiproliferativa en las células de cáncer de mama, pero sus componentes funcionales y mecanismo antitumoral aún no están claros. En esta investigación se analizaron los principales componentes activos de los frutos de A. bunius (detectados por UHPLC-MS / MS) y las dianas correspondientes mediante el método de farmacología en red, y se verificaron sus interacciones mediante acoplamiento molecular para explorar los posibles mecanismos supresores de tumores. Se seleccionaron un total de 24 componentes químicos activos del extracto de frutas de A. bunius, y 44 genes diana se cruzaron con el cáncer de mama, entre ellos, AKT1, ESR1, EGFR, EP300, ERBB2 y AR fueron los principales objetivos principales. de los genes diana involucraban principalmente procesos de metabolismo de lípidos celulares, respuesta a hormonas, desarrollo de tubos y centros de análisis de la vía KEGG en las vías del cáncer presentes en el cáncer de mama, páncreas y pulmón de células no pequeñas．Los flavonoides en los frutos de A. bunius mostraron fuertes unión a los objetivos centrales mediante análisis de acoplamiento molecular. Estos resultados sugieren fuertemente que los flavonoides en la fruta de A. bunius pueden inhibir la proliferación del cáncer de mama a través de múltiples dianas, principalmente por las vías ERK y PI3K-AKT.
Citas
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
Derechos de autor 2021 Funing MA, Jorge Luis Gutierrez-Pajares, Dongmei HUANG, Yi XU, Bin WU, Shun SONG