Efficacy of oral antiparasitics in the treatment and control of gastrointestinal nematodes in horses
PDF (Español (España))

Keywords

eficacia antiparasitaria
nematodiasis
yeguas
coproparasitología antiparasitic efficacy
nematodiasis
mares
coproparasitología

How to Cite

Oliva Santillan, M., León-Gallardo, Z., Alarcón Gutierrez, W. N., Ramírez Sanchez, J. M., & Rodríguez Rosales, C. S. (2021). Efficacy of oral antiparasitics in the treatment and control of gastrointestinal nematodes in horses. Tayacaja, 4(1), 145–155. https://doi.org/10.46908/tayacaja.v4i1.160

Abstract

The objective of the study was to determine the efficacy of two oral antiparasitics in the control of gastrointestinal nematodes in horses. 45 mares from 2 to 4 years old were randomly distributed into three groups: I: control group, II: antiparasitic treatment. doramectin in doses of 11.4 mg / kg of body weight and III: treatment with antiparasitic fenbendazole in doses of 7.5 mg / kg of body weight, with 15 repetitions each. Stool samples were collected prior to dosing and 30 days after treatment. The fecal samples were analyzed using the modified Baermann cup technique, Kato-Katz and the Graham test. Pre and post treatment data were analyzed with parametric and non-parametric tests. The efficacy of the treatments was determined by the method of percentage reduction of eggs per gram of feces (hpg). All mares were positive for nematodes, identifying Strongylus sp, Parascaris sp and Oxyuris sp. The efficacy of doramectin was 97% and fenbendazole 51% (p <0.05).

https://doi.org/10.46908/tayacaja.v4i1.160
PDF (Español (España))

References

Beltran M, Tello CR, Náquira VC. (2014). Manual de procedimientos de laboratorio para el diagnóstico de los parásitos intestinales del hombre (Serie de Normas Técnicas 37). Lima, Perú: Instituto Nacional de Salud. 104 p. Burn CC, Dennison TL, Whay HR. (2009). Environmental and demographic risk factors for poor welfare in working horses, donkeys and mules in developing countries. Vet J 186: 385-392. DOI: 10.1016/j.tvjl.2009.09.016.

Canaver RJ, Braga PRC, Boeckh A, Grycajuck M, Bier D, Molento MB. (2013). Lack of Cyathostomin sp. Reduction after anthelmintic treatment in horses in Brazil. Vet Parasitol; 194:35-39.

Cardona E, Choperena M, Quijano J, López G. (2005). Caracterización de nematodos gastrointestinales de equinos que llegan a la central ganadera de Medellín. Rev Cienc Pec 4: 384-385.

Cerna F. (2007). Estudio comparativo de la efectividad de dos lactonas macrocíclicas, administradas por vía oral e intramuscular en equinos. Tesis de pregrado. Chile. Universidad Austral de Chile. 28 p.

Coles GC, Bauer C, Borgsteede FH, Geerts S, Klei TR, Taylor MA, Waller PJ. (1992). World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol 44:35-44.

Chaparro- Gutiérrez J, Ramírez-Vásquez N, Piedrahita D, Strauch A, Sánchez A, Tobón J, Olivera-Ángel M, Ortiz-Ortega D, ViLLarArgaiz D. (2018). Prevalencia de parásitos gastrointestinales en equinos y factoresde riesgo asociados en varias zonas de Antioquia, Colombia. CES Medicina Veterinaria y Zootecnia, vol. 13, núm. 1, 2018. DOI: 10.21615/cesmvz.13.1.1.

Chávez A, Casas G, Casas E. (2007). Evaluación de la eficacia de un antiparasitario en solución conteniendo Triclabendazole, Ivermectina y Fenbendazole (Triverfen®22.2), para el control de la nematodiasis gastrointestinal en equinos. Perú.

Chávez L. (2013). Doramectina oral para el tratamiento y control de parásitos internos en caballos.

Doménech, C. I., Marcet, S. R., Figueredo, P. M., & Sarracent, P. J. (2009). Conservación de heces humanas para la detección de antígenos de excreción-secreción de Fasciola hepatica. Rev. Cubana. Med. Trop., 61(2), 1-5.

Francisco R, Paz-Silva A, Francisco I, Cortiñas F, Miguelez S, Suarez J, CazapalMonteiro C, Arias M, Sanchez R. (2012). Preliminary analysis of the results of selective therapy against Strongylus in pasturing horses. J Equine Vet Sci 32: 274-280. DOI: 10.1016/j.jevs.2011.09.074.

Garcia A, Brady HA, Nichols WT, Prien S. (2013). Equine cyathostomin resistance to fenbendazole in Texas horse facilities. J Equine Vet Sci 33: 223- 228. DOI: 10.1016/j.jevs.2012.06.005.

Gutiérrez SO, Gutiérrez FD. (2013). Teniasis en equinos de servicio público de la ciudad de Trinidad, Bolivia. Rev Cient Agro Amaz. 1: 43-47.

Hendrix CM. (1999). Diagnóstico Parasitológico Veterinario. España: Harcourt-Brace.

Herrera Y, Perdomo S, Cardana J. (2015). Eficacia de la doramectina via intramuscular en nematodos gastrintestinales en equinos. Rev Med Vet 29: 41-49. DOI: 10.19052/mv.3445.

Herrera Y, Vergara J, Ensuncho C, Causil L. (2016). Frecuencia de parásitos gastrointestinales en burros criollos (Equus africanus asinus) en el departamento de Córdoba, Colombia. Rev Colombi Cienc Anim 8:159- 166. DOI: 10.24188/recia.v8.n2.2016.183.

Herrera Benavides, Yonairo Manuel, Perdomo Ayola, Sandra Carolina, & Cardona Álvarez, José Alberto. (2015). Eficacia de la doramectina vía intramuscular en nematodos gastrointestinales en equinos. Revista de Medicina Veterinaria, (29), 41-49.

Instituto Nacional de Salud (2014). Manual de procedimientos de laboratorio para el diagnóstico de los parásitos intestinales del hombre. Serie de Normas Técnicas 37. 104 pp. Lima- Peru.

Kaplan RM. (2005). Current concepts for parasite control in horses: it ain’t the 60’s anymore. Proceedings of the Kentucky Veterinary Medical Association, Morehead, Kentucky, USA, Pp 1-13.

Kassai, T. (2002). Helmintología Veterinaria, 1a Edición. Editorial Acribia S.A., Zaragoza-España. pp 4-13; 147-161.

Lester HE, Spanton J, Stratford CH, Bartley DJ, Morgan ER, Hodgkinson JE, Coumbe K, et al. (2013). Anthelmintic efficacy against cyathostomins in horses in Southern England. Vet Parasitol 197: 189- 196. DOI: 10.1016/j.vetpar.2013.06.009.

Lester HE, Matthews JB. (2014). Faecal worm egg count analysis for targeting anthelmintic treatment in horses: points to consider. Equine Vet J 46: 139-145. DOI: 10.1111/evj.12199.

Lyons ET, Tolliver SC. (2004). Prevalence of parasite eggs (Strongyloides westeri, Parascaris equorum, and Strongylus) and oocysts (Emeria leuckarti) in the feces of thoroughbred foals on 14 farms in central Kentucky in 2003. Vet Parasitol 5: 400- 404. DOI: 10.1007/s00436-003-1068-2.

Lyons ET, Tolliver SC, Collins SS. (2006). Field studies on endoparasites of thoroughbred foals on seven farms in central Kentucky. Vet Parasitol 98: 496-500.

Matto TN, Bharkad GP, Bhat SA. (2015). Prevalence of gastrointestinal helminth parasites of equids from organized farms of Mumbai and Pune. J Parasitic Dis 39: 179-185. DOI: 10.1007/s12639-013-0315-4.

Matthews JB. (2008). An update on cyathostomins: anthelmintic resistance and worm control. Equine Vet Educ 20: 552-560. DOI: 10.2746/095777308X363912.

Matthews JB. (2014). Anthelmintic resistance in equine nematodes. Int J Parasitol-Drug 4: 310-315. DOI: 10.1016/j.ijpddr.2014.10.003.

Molento MB, Kielsen MK, Kaplan RM. (2012). Resistance to avermectin/milbemycin anthelmintics in equine cyathostomins - Current situation. Vet Parasit; 185:16- 24. DOI: 10.1016 / j.vetpar.2011.10.013

Morales A, Bello H, Vallejo M, Villoria D. (2012). Prevalencia de parásitos gastrointestinales en equinos Pura Sangre de Carrera durante el período de cuarentena 2011 en el hipódromo “La Rinconada” Caracas, Venezuela. Rev Ibero-Latinoam Parasitol 6: 15-119.

Nielsen M. (2012). Sustainable equine parasite control: perspectives and research needs. Vet Parasitol 185: 32- 44. DOI: 10.1016/j.vetpar.2011.10.012.

Osterman E. (2005). Prevalence and control of Strongyle nematode infections of horses in Sweden. Doctoral Thesis. Uppsala, Sweden: Swedish University of Agricultural Sciences. 61 p.

Peregrine AS, Molento MB, Kaplan RM, Nielsen MK. (2014). Anthelmintic resistance in important parasites of horses: does it really matter? Vet Parasitol 201: 1-8. DOI: 10.1016/j.vetpar.2014.01.004.

Pérez R, Godoy C, Palma C, Muñoz L, Arboix M, Alvinerie M. (2010). Plasma disposition and fecal elimination of doramectin after oral or intramuscular administration in horses. Vet Parasitol 170: 112-119. DOI: 10.1016/j.vetpar.2010.01.038.

Piccoli C, Marques SMT, Appel G, Silveira E, Siqueira GB, Loos DE, Mattos MJT. (2015). Helmintos intestinalis em cavalos de trabalho e de lazer de Porto Alegre/RS. Sci Anim Health 3: 56-64. DOI: 10.15210/sah.v3i1.4227.

Pietrzak-Johnston SM, Bishop H, Wahlquist S, Moura H, De Oliveira Da Silva N, Pereira Da Silva S, Nguyen-Dinh P. (2020). Evaluation of commercially available preservatives for laboratory detection of helminths and protozoa in human fecal specimens. J Clin Microbiol. 38:1959-64. DOI: 10.1128 / JCM.38.5.1959-1964.2000

Prokulewicz A, Pilarczyk B, Tomza-Marciniak A. (2014). Evaluation of the efficacy of doramectin in the control of strongyle (strongylidae, cyathostominae) infestation in Horses. Isr J Vet Med 69: 83-87.

Proudman, C., & Matthews, J. (2000). Control of intestinal parasites in horses. Equine Practice, 22, 90-97.

Reinemeyer C. (2008). Parasite control for horses during the first year of life. In: Proc American Association of Equine Practitioners. Austin, Texas, USA.

Reinemeyer C.R. (2009). Controlling strongyle parasites of horses: a mandate for change. In: Proc 55th Annual Convention of the American Association of Equine Practitioners. Las Vegas, Nevada, USA. Pp 352-360.

Reinemeyer CR. (2012). Anthelmintic resistance in non-strongylid parasites of horses. Vet Parasitol 185: 9-15. DOI: 10.1016/j.vetpar.2011.10.009.

Rodríguez-Vivas R Ligia A. Cob-Galera, J. Domínguez-Alpizar. (2001). Frecuencia de parásitos gastrointestinales en animales domésticos diagnosticados en Yucatán, México. Revista Biomédica Vol. 12 N 1. DOI: doi.org/10.32776/revbiomed.v12i1.253.

Rojas M. (2004). Nosoparasitosis de los rumiantes domésticos peruanos. 2° ed. Lima, Perú. Martegraf. 146 p.

Salas R, Mencho JD, Guerra L, Mencho JC. (2014). Prevalencia de nematodos intestinales y eficacia de Labiomec® en caballos de Camagüey, Cuba. Rev Salud Anim 36: 152-158.

Salas-Romero J, Gómez-Cabrera K, Molento M, Lyon ET, Delgado A, González L, Arenal A, Nielsen M. (2017). Efficacy of two extra-label anthelmintic formulations against equine strongyles in Cuba. Vet Parasitol Reg Stud Rep 8: 39-42. DOI: 10.1016/j.vprsr.2017.01.010.

Salas-Romero J., Gómez K., Chicoy Y., Yero C., Valle E., Delgado-Martínez A., Salas-Romero J., Arenal A. (2017). Especies de ciatostomas resistentes al albendazol en equinos, Cuba. Rev Inv Vet Perú 28: 658-666. DOI: 10.15381/rivep.v28i3.13347.

Sarmiento L, Tantaleán M, Huiza A. (1999). Nematodos parásitos del hombre y de los animales en el Perú. Rev Peruana Parasit, 14(1-2): 9-65.

Sumano L, Ocampo C. (1997). Farmacología veterinaria. 2a. ed. México: McGraw-Hill Interamericana.

Steffan, P., Fiel, C., Saumell, C., Fusé, C., Iglesias, L. (2014). El uso de antihelmínticos en los programas de control y el riesgo potencial de resistencia. Pp 85–94.

Stratford CH, Lester HE, Pickles KJ, McGorum BC, Matthews JB. (2013). An investigation of anthelmintic efficacy against strongyles on equine yards in Scotland. Equine Vet J 46: 17-24. DOI: 10.1111/evj.12079.

Scott I, Bishop R, Pomroy W. (2015). Anthelmintic resistance in equine helminth parasites–a growing issue for horse owners and veterinarians in New Zealand? New Zeal Vet J 63: 188-198. DOI: 10.1080/00480169.2014.987840.

Tang J, Ledesma V. (2006). Evaluación de tolerancia y eficacia de un endectocida en gel sobre la base de doramectina (doraQuest l.A.) en el tratamiento de parasitosis internas de caballos de salto.

Tang J, Ruiz F, Rodriguez L. (2008). Evaluación de tolerancia y eficacia inmediata de un endectocida en gel sobre la base de doramectina al 1,75% (doraQuest l.a.) en el tratamiento y control de parasitosis internas en equinos de la sierra central. Agrovetmarket.

Teixeira WF, Felippelli G, Cruz BC, Maciel WG, Fávero FC, Gomes LV, Buzzulini C, Prando L, Bichuette MA, Lopes WD, Oliveira GP, Costa AJ. (2014). Endoparasites of horses from the Formiga city, located in center-west region of the state of Minas Gerais, Brazil. Rev Bras Parasitol V 23: 534- 538. DOI: 10.1590/s1984-29612014072.

Thienpont D, Rochette F, Vanpaijs O.(1986). Diagnóstico de las helmintiasis por medio del examen coprológico. 2da ed.Bélgica: Janssen Research Fundation.

Upjohn MM, Shipton K, Lerotholi T, Attwood G, Verheyen KL. (2010). Coprological prevalence and intensity of helminth infection in working horses in Lesotho. Trop Anim Health Pro 42: 1655-1661. DOI: 10.1007/s11250-010-9617-z.

Varady M, Konigova A, Corba J. (2004). A field study to evaluate the efficacy of fenbendazole on 9 stud farms. Vet Med-Czech 49: 42-46.

Infestaciones parasitarias en los caballos. [Internet].

Vidyashankar AN, Hanlon BM, Kaplan RM. (2012). Statistical and biological considerations in evaluating drug efficacy in equine strongyle parasites using fecal egg count data. Vet Parasitol 185: 45- 56. DOI: 10.1016/j.vetpar.2011.10.011.

Von Samson-Himmelstjerna G. (2012). Anthelmintic resistance in equine parasites detection, potential clinical relevance and implications for control. Vet Parasitol 185: 2-8. DOI: 10.1016/j.vetpar.2011.10.010.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2021 Mirta Oliva Santillan, Zara León-Gallardo, Willman Neptalí Alarcón Gutierrez, Julia Mercedes Ramírez Sanchez, Catalina Silvia Rodríguez Rosales

Downloads

Download data is not yet available.