Abstract
Cancer is a worldwide disease that affects millions of people every year. Although there are several approved chemotherapeutic drugs for cancer treatment, there is s constant search for new molecules. This search is supported by the need of new molecules that could target cancer cells specifically reducing side effects or that could act synergistically with approved anticancer drugs. In this review, research on flower extracts and flower-derived molecules is presented.
References
Al-Harbi, Laila Naif, Pandurangan Subash-Babu, Manal Abdulaziz Binobead, Maha Hussain Alhussain, Sahar Abdulaziz AlSedairy, Amal A. Aloud, and Ali A. Alshatwi. (2020) “Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea Stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, PRb2, P53 and Downregulation of PCNA MRNA Expressions.” Metabolites 10(7). DOI: 10.3390/metabo10070280.
Al-Oqail, Mai Mohammad, Amina El-Shaibany, Ebtesam Al-Jassas, Ebtesam Saad AlSheddi, Shaza Mohamed Al-Massarani, and Nida Nayyar Farshori. (2016). “In Vitro AntiProliferative Activities of Aloe Perryi Flowers Extract on Human Liver, Colon, Breast, Lung, Prostate and Epithelial Cancer Cell Lines.” Pakistan Journal of Pharmaceutical Sciences 29(2 Suppl):723–29.
Arrondeau, Jennifer, Hui K. Gan, Albiruni R. A. Razak, Xavier Paoletti, and Christophe Le Tourneau. (2010). “Development of Anti-Cancer Drugs.” Discovery Medicine 10(53):355–62.
Blagosklonny, Mikhail V. (2004). “Analysis of FDA Approved Anticancer Drugs Reveals the Future of Cancer Therapy.” Cell Cycle (Georgetown, Tex.) 3(8):1035–42.
Bray, Freddie, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L. Siegel, Lindsey A. Torre, and Ahmedin Jemal. 2018. “Global Cancer Statistics (2018): GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.” CA: A Cancer Journal for Clinicians 68(6):394–424. DOI: 10.3322/caac.21492.
Chen, Szu-Jung, Yuan-Chiang Chung, HanLung Chang, Hsin-Ping Chang, Jui-Ling Chou, Chih-Cheng Lin, Chih-Hsien Chen, and Chih-Ping Hsu. (2020). “Synergistic Effect of Combined Treatment with Longan FlowerExtract and 5-Fluorouracil on Colorectal Cancer Cells.” Nutrition and Cancer 72(2):209– 17. DOI: 10.1080/01635581.2019.1622739.
Choedon, Tenzin, Surendra Kumar Shukla, and Vijay Kumar. (2010). “Chemopreventive and Anti-Cancer Properties of the Aqueous Extract of Flowers of Butea Monosperma.” Journal of Ethnopharmacology 129(2):208– 13. DOI: 10.1016/j.jep.2010.03.011.
Conforti, Filomena, Federica Menichini, Daniela Rigano, and Felice Senatore. (2009). “Antiproliferative Activity on Human Cancer Cell Lines after Treatment with Polyphenolic Compounds Isolated from Iris Pseudopumila Flowers and Rhizomes.” Zeitschrift Fur Naturforschung. C, Journal of Biosciences 64(7–8):490– 94. DOI: 10.1515/znc-2009-7-804.
Gautam, Vandana, Anket Sharma, Saroj Arora, Renu Bhardwaj, Ajaz Ahmad, Bilal Ahamad, and Parvaiz Ahmad. (2020). “In-Vitro Antioxidant, Antimutagenic and Cancer Cell Growth Inhibition Activities of Rhododendron Arboreum Leaves and Flowers.” Saudi Journal of Biological Sciences 27(7):1788– 96. DOI: 10.1016/j.sjbs.2020.01.030.
Goodman, Jordan, Vivien Walsh, and Professor in Innovation Management Manchester Business School Vivien Walsh. (2001). The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug. Cambridge University Press.
Hanahan, Douglas, and Robert A. Weinberg. (2011). “Hallmarks of Cancer: The next Generation.” Cell 144(5):646–74. DOI: 10.1016/j.cell.2011.02.013.
Jaradat, Nidal Amin, Rowa Al-Ramahi, Abdel Naser Zaid, Ola Ibrahim Ayesh, and Ahmad Mustafa Eid. (2016). “Ethnopharmacological Survey of Herbal Remedies Used for Treatment of Various Types of Cancer and Their Methods of Preparations in the West Bank-Palestine.” BMC Complementary and Alternative Medicine 16(1):93. DOI: 10.1186/s12906-016-1070-8.
Khazaei, Somayeh, Roslida Abdul Hamid, Vasudevan Ramachandran, Norhaizan Mohd Esa, Ashok Kumar Pandurangan, Fatemeh Danazadeh, and Patimah Ismail. (2017). “Cytotoxicity and Proapoptotic Effects of Allium Atroviolaceum Flower Extract by Modulating Cell Cycle Arrest and Caspase-Dependent and P53- Independent Pathway in Breast Cancer Cell Lines.” Evidence-Based Complementary and Alternative Medicine: ECAM 2017:1468957. DOI: 10.1155/2017/1468957.
Khazaei, Somayeh, Vasudevan Ramachandran, Roslida Abdul Hamid, Norhaizan Mohd Esa, Ali Etemad, Sara Moradipoor, and Patimah Ismail. (2017). “Flower Extract of Allium Atroviolaceum Triggered Apoptosis, Activated Caspase-3 and down-Regulated Antiapoptotic Bcl-2 Gene in HeLa Cancer Cell Line.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 89:1216– 26. DOI: 10.1016/j.biopha.2017.02.082.
Kim, Hyoung-Geun, Hyun-Ji Oh, Jung-Hwan Ko, Hae Seong Song, Yeong-Geun Lee, Se Chan Kang, Dae Young Lee, and Nam-In Baek. (2019). “Lanceoleins A-G, Hydroxychalcones, from the Flowers of Coreopsis Lanceolata and Their Chemopreventive Effects against Human Colon Cancer Cells.” Bioorganic Chemistry 85:274–81. DOI: 10.1016/j.bioorg.2019.01.003.
Lin, Liyan, Peipei Wang, Zhenyun Du, Wucheng Wang, Qifei Cong, Changping Zheng, Can Jin, Kan Ding, and Chenghao Shao. (2016). “Structural Elucidation of a Pectin from Flowers of Lonicera Japonica and Its Antipancreatic Cancer Activity.” International Journal of Biological Macromolecules 88:130– 37. DOI: 10.1016/j.ijbiomac.2016.03.025.
M Elkady, Wafaa, Iriny M Ayoub, Yousra AbdelMottaleb, Mohamed F. ElShafie, and Michael Wink. (2020). “Euryops Pectinatus L. Flower Extract Inhibits P-Glycoproteinand Reverses Multi-Drug Resistance in Cancer Cells: A Mechanistic Study.” Molecules (Basel, Switzerland) 25(3). DOI: 10.3390/molecules25030647.
Managit, Chittima, Hiroaki Sakurai, and Ikuo Saiki. (2017). “Ethanolic Extract of Thevetia Peruviana Flowers Enhances TNF-α and TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via Intrinsic and Extrinsic Pathways.” Oncology Letters 13(4):2791–98. DOI: 10.3892/ol.2017.5748.
Nguyen, Christopher, Kiruthika Baskaran, Alaina Pupulin, Ivan Ruvinov, Ola Zaitoon, Sahibjot Grewal, Benjamin Scaria, Ali Mehaidli, Caleb Vegh, and Siyaram Pandey. (2019). “Hibiscus Flower Extract Selectively Induces Apoptosis in Breast Cancer Cells and Positively Interacts with Common Chemotherapeutics.” BMC Complementary and Alternative Medicine 19(1):98. DOI: 10.1186/s12906-019-2505-9.
Remya, R. R., S. R. Radhika Rajasree, L. Aranganathan, and T. Y. Suman. (2015). “An Investigation on Cytotoxic Effect of Bioactive AgNPs Synthesized Using Cassia Fistula Flower Extract on Breast Cancer Cell MCF-7.” Biotechnology Reports (Amsterdam, Netherlands) 8:110–15. DOI: 10.1016/j.btre.2015.10.004.
Rojas-Armas, Juan Pedro, Jorge Luis Arroyo Acevedo, José Manuel Ortiz-Sánchez, Miriam Palomino-Pacheco, Oscar HerreraCalderón, James Calva, Agustín Rojas-Armas, Hugo Jesús Justil-Guerrero, Américo CastroLuna, and Julio Hilario-Vargas. (2020). “Cordia Lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats.” Evidence-Based Complementary and Alternative Medicine 2020:1–8. DOI: 10.1155/2020/5062942.
Saleh, Ayman M., Mahmoud A. Al-Qudah, Amre Nasr, Sayed A. Rizvi, Anwar Borai, and Mustafa Daghistani. (2017). “Comprehensive Analysis of the Chemical Composition and In Vitro Cytotoxic Mechanisms of Pallines Spinosa Flower and Leaf Essential Oils Against Breast Cancer Cells.” Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 42(5):2043–65. DOI: 10.1159/000479900.
Samouh, Yassine, Asmaa Lemrani, Hajar Hajar, Jaoud Mohamad, and Amal Ait Haj Said. (2019). “Ethnopharmacological Study of Herbal Medicines Used to Treat Cancer in Morocco.” The Journal of Phytopharmacology 8(3):135–41. DOI: 10.31254/phyto.2019.8309.
Seo, Jina, Jungjae Lee, Hyi Young Yang, and Jihyeung Ju.( 2020). “Antirrhinum Majus L. Flower Extract Inhibits Cell Growth and Metastatic Properties in Human Colon and Lung Cancer Cell Lines.” Food Science & Nutrition 8(11):6259–68. DOI: 10.1002/fsn3.1924.
Subramaniyan, Boopathi, Vijay Kumar, and Ganeshan Mathan. (2017). “Effect of Sodium Salt of Butrin, a Novel Compound Isolated from Butea Monosperma Flowers on Suppressing the Expression of SIRT1 and Aurora B Kinase Mediated Apoptosis in Colorectal Cancer Cells.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 90:402– 13. DOI: 10.1016/j.biopha.2017.03.086.
Subramaniyan, Boopathi, Navaneethakrishnan Polachi, and Ganeshan Mathan. (2016). “Isocoreopsin: An Active Constituent of n-Butanol Extract of Butea Monosperma Flowers against Colorectal Cancer (CRC).” Journal of Pharmaceutical Analysis 6(5):318– 25. DOI: 10.1016/j.jpha.2016.04.007.
Sun, Jingchun, Qiang Wei, Yubo Zhou, Jingqi Wang, Qi Liu, and Hua Xu. 2017. “A Systematic Analysis of FDA-Approved Anticancer Drugs.” BMC Systems Biology 11(Suppl 5):87. DOI: 10.1186/s12918-017-0464-7.
Tan, G., C. Gyllenhaal, and D. D. Soejarto. (2006). “Biodiversity as a Source of Anticancer Drugs.” Current Drug Targets 7(3):265–77. DOI: 10.2174/138945006776054942T
sai, Yu-Ling, Chien-Chih Chiu, Jeff Yi-Fu Chen, Kung-Chi Chan, and Sheng-Dun Lin. (2012). “Cytotoxic Effects of Echinacea Purpurea Flower Extracts and Cichoric Acid on Human Colon Cancer Cells through Induction of Apoptosis.” Journal of Ethnopharmacology 143(3):914– 19. DOI: 10.1016/j.jep.2012.08.032.
Wani, M. C., H. L. Taylor, M. E. Wall, P. Coggon, and A. T. McPhail. (1971). “Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus Brevifolia.” Journal of the American Chemical Society 93(9):2325–27. DOI: 10.1021/ja00738a045
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